First, it is one of the only Lion's Mane mushroom products on the market with a human double-blind, placebo controlled clinical trial (https://appliedfoods.com/introducing-mycothrive-lions-mane-a-clinically-studied-ingredient-for-cognitive-performance/)supporting it's cognitive benefits. Second, it is third party batch tested to confirm bioactive ingredients (including hericenes, not just polysaccharides or beta glucans) and that it does not contain anything it should not. Third, it is a 12:1 fruiting body extract. Click here (https://www.nordicmushrooms.com/quality)for a transparent supply chain. Here is a white paper detailing the quality control: White Paper – Nordic Mushrooms(https://www.nordicmushrooms.com/white-paper/) The fruiting body contains hericene A, which is a newly discovered bioactive component in Lion's Mane that supports the production of new neural pathways.(https://onlinelibrary.wiley.com/doi/10.1111/jnc.15767) https://static.wixstatic.com/media/e94a19_0dbfc7419b09476fa781ebb75b020ad5~mv2.png

To replicate the human clinical trial showing cognitive benefits, you would take 2 capsules in the morning (with or without food). You can choose to take another dose later in the day if you would like to increase potential benefits.

Lion's Mane has GRAS status (generally recognized as safe) according to the FDA and does not have hepatotoxicity.(https://www.ncbi.nlm.nih.gov/books/NBK599740/) Additionally, the MycoThrive™ Lion’s Mane in our product was found to be safe and effective in a human clinical trial. If you are taking medications, you should check with your healthcare provider before starting any supplements. Lion's Mane may have blood-thinning effects, so you should not take it with blood thinning medications. Lion's Mane may lower blood sugar, so use caution if you are on medications that may lower blood sugar. If you are pregnant or nursing, you should not take Lion's Mane as it has not been studied in that regard.

While everyone responds differently, we can refer to the actual double-blind cross-over study (https://appliedfoods.com/introducing-mycothrive-lions-mane-a-clinically-studied-ingredient-for-cognitive-performance/)done on our ingredient (Mycothrive), in which participants noticed immediate improvements (within 60-120minutes): "Lion’s Mane demonstrated acute improvements in working memory, attention, concentration, and reaction time that were statistically significant compared to the placebo. Additionally, MycoThrive™ Lion’s Mane helped improve the participants’ mood and sense of happiness compared to their peers, reflecting a significant impact on contentment and emotional well-being.[ii]"

Lion's Mane mushroom increases the production of NGF (nerve growth factor) and BDNF (brain derived neurotrophic factor) and it's components (hericenes and erinacenes) easily pass the blood-brain barrier. These secondary metabolites from Lion's Mane have neuro-protective and neurotrophic (growth of new nerve tissue) effects. In 2023, researchers discovered another pathway in which a molecule called hericene a found in the fruiting body works through a new signaling pathway called ERK1/2. Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory - PubMed(https://pubmed.ncbi.nlm.nih.gov/36660878/)